Nelson Higher Education

Higher Education

Biochemistry, 1st Edition

  • Reginald H. Garrett
  • Charles M. Grisham
  • Stavroula Andreopoulos
  • William G. Willmore
  • Imed E. Gallouzi
  • ISBN-10: 0176502653
  • ISBN-13: 9780176502652
  • 0 Pages | Paperback
  • Previous Editions: 2017, 2013, 2009
  • COPYRIGHT: 2013 Published
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Overview

About the Product

Biochemistry 1st Canadian edition guides students through course concepts in a way that reveals the beauty and usefulness of biochemistry in the everyday world from a unique Canadian context. Biochemistry is a living science that touches every aspect of our lives and this book ensures students are made aware of the significance and interdisciplinary nature of this subject; questions posed at the beginning of each chapter and new “Why it Matters” boxes grab interest and tap into students inner ‘scientist’ answering why and how topics are relevant and important, “Human Biochemistry” features highlight how biochemistry affects our bodies, as well as “Critical Developments” sections focus on various types of drug design. Highlighting the most current research topics such as mRNA turnover and microRNA, as well as Canadian researchers and institutions, the 1st Canadian edition of Biochemistry will help students master the concepts of biochemistry and gain new insight into this dynamic science.

Features

  • Current and international references have been included in all chapters

  • Human Biochemistry boxes have been updated to include more Canadian and international scientists, including their affiliations

  • Conceived and developed by Chemistry instructors for Chemistry courses at the University of Massachusetts, Amherst, OWL is the most widely-used online chemistry solution in the world. OWL not only saves instructors time but also solves the very real teaching and learning problems that instructors and students face in the classroom.

About the Author

Reginald H. Garrett

Reginald H. Garrett was educated in the Baltimore city public schools and at the Johns Hopkins University, where he received his Ph.D. in biology in 1968. Since that time, he has conducted research and taught biochemistry courses at the University of Virginia, where he is currently Professor of Biology. He is the author of numerous papers and review articles on biochemical, genetic, and molecular biological aspects of inorganic nitrogen metabolism. His early research focused on the pathway of nitrate assimilation in filamentous fungi. His investigations contributed substantially to our understanding of the enzymology, genetics, and regulation of this major pathway of biological nitrogen acquisition. More recently, he has collaborated in systems approaches to the metabolic basis of nutrition-related diseases. His research has been supported by grants from the National Institutes of Health, the National Science Foundation, and private industry. A member of the American Society for Biochemistry and Molecular Biology, Garrett is a former Fulbright Scholar, was twice Visiting Scholar at the University of Cambridge, and was Invited Professor at the University of Toulouse, France.

Charles M. Grisham

Charles M. Grisham received his B.S. in chemistry from the Illinois Institute of Technology in 1969 and his Ph.D. in chemistry from the University of Minnesota in 1973. Following a postdoctoral appointment at the Institute for Cancer Research in Philadelphia, he became Professor of Chemistry at the University of Virginia, where he teaches biochemistry, introductory chemistry, and physical chemistry. He has authored numerous papers and review articles on active transport of sodium, potassium, and calcium in mammalian systems, on protein kinase C, and on the applications of NMR and EPR spectroscopy to the study of biological systems. His work has been supported by the National Institutes of Health, the National Science Foundation, the Muscular Dystrophy Association of America, the Research Corporation, the American Heart Association and the American Chemical Society. A member of the American Society for Biochemistry and Molecular Biology, Grisham held the Knapp Chair in Chemistry in 1999 at the University of San Diego; was Visiting Scientist at the Aarhus University Institute of Physiology, Aarhus, Denmark, for two years; and received a Research Career Development Award from the National Institutes of Health.

Stavroula Andreopoulos

Stavroula Andreopoulos, PhD is a Senior Lecturer and Acting Undergraduate Coordinator in the department of Biochemistry at the University of Toronto. Stavroula is a passionate teacher who coordinates second and third year undergraduate Biochemistry courses with over 1700 students registered from a wide variety of programs. She earned her M.Sc. and Ph.D. at U of T. While she began her work in biochemistry as a researcher at the University of Athens and the Centre for Addiction and Mental Health examining both the molecular mechanisms aspects of soluble guanylyl cyclase and lithium regulation of TRPC ion channels in bipolar disorder, her primary interest and love is now in teaching. She is the recipient of several awards, including: the NCDEU New Investigator's Awardee-National Institute of Mental Health (NIMH); the Center for Addiction and Mental Health (CAMH) Fellowship Award; and more recently, the Excellence in Undergraduate Teaching in Life Sciences Award in 2011.

William G. Willmore

William Willmore, PhD is an Associate Professor in the Institute of Biochemistry, Departments of Biology and Chemistry at Carleton University. Bill teaches the second and third year Biochemistry courses at Carleton where he also leads a team researchers examining the role of hydroxylation in ischemic cardiovascular diseases and stroke (research that creates new therapies for patient recovery from cardiac arrest and stroke). Dr. Willmore received his Ph.D. in Biochemistry from the University of Carleton, and was also the recipient of an Ontario Early Researcher Award in 2006.

Imed E. Gallouzi

Imed-Eddine Gallouzi, PhD, is an Associate Professor in the Department of Biochemistry at McGill University, Montreal. Professor Gallouzi is also a TierII Canada Research Chair in Cellular Information Systems. In 1998 he obtained his PhD in Molecular and Celluar Biology in CNRS, Montpellier, France. His primary area of research is in Messenger RNA (mRNA) stability influences gene expression in virtually all organisms, with the focus on mammals. Gallouzi’s laboratory specializes in the study of RNA binding proteins and the various roles they play in physiological and pathological processes. He focuses on delineating the regulatory mechanisms that modulate mRNA expression during cell death and muscle formation. He is also testing the use of chemicals to interfere with muscle wasting induced by various diseases such as cancer, AIDS and sepsis. Dr. Gallouzi's program at McGill University creates a new centre of excellence in cell biology at the institution, and his training activities have generated a strong team of cross-disciplinary researchers who bring expertise in biochemistry, cell biology and molecular biology technologies to bear on the challenging problems related to cancer cell development and growth.

Table of Contents

Part One: Fundamental Components/Building Blocks of the Cell
Chapter 1: The Facts of Life: Chemistry is the Logic of Biological Phenomena
Chapter 2: Water: The Medium of Life
Chapter 3: Thermodynamics of Biological Systems
Chapter 4: Amino Acids
Chapter 5: Proteins: Their Primary Structure and Biological Functions
Chapter 6: Proteins: Secondary, Tertiary, and Quaternary Structure
Chapter 7: Carbohydrates and the Glycoconjugates of Cell Surfaces
Chapter 8: Lipids
Chapter 9: Lipid Biosynthesis
Chapter 10: Membranes an Membrane Transport
Chapter 11: The Reception and Transmission of Extracellular Information

Part Two: Protein Dynamics
Chapter 12: Enzymes: Kinetics and Specificity
Chapter 13: Mechanisms of Enzyme Action
Chapter 14: Enzyme Regulation
Chapter 15: Molecular Motors

Part Three: Metabolism and Its Regulation
Chapter 16: Nutrition and the Organization of Metabolism
Chapter 17: Glycolysis
Chapter 18: The Tricarboxylic Acid Cycle
Chapter 19: Electron Transport and Oxidative Phophorylation
Chapter 20: Photosynthesis
Chapter 21: Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway
Chapter 22: Fatty Acid Catabolism

Part Four: Nucleic Acids
Chapter 23: Nucleotides and Nucleic Acids
Chapter 24: Structure of Nucleic Acids
Chapter 25: Synthesis and Degradation of Nucleotides
Chapter 26: Recombinant DNA: Cloning and Creation of Chimeric Genes
Chapter 27: DNA Metabolism: Replication, Recombination, and Repair

Part Five: Information Transfer
Chapter 28: Transcription and the Regulation of Gene Expression
Chapter 29: Protein Synthesis
Chapter 30: Posttranscriptional Regulation of Gene Expression: mRNA Turnover and microRNA
Chapter 31: Completing the Protein Life Cycle: Folding, Processing, and Degradation
Chapter 32: Metabolic Integration and Organ Specialization

New to this edition

  • The table of contents has been revised for a more effective organization of chapters
  • New box feature has been added: Why It Matters –makes content relevant to students by tying material back to ‘real-life’
  • New box feature has been added: Biochemistry; A Canadian Context – highlights Canadian content to give relevance to Canadian students
  • New chapter has been included: Chapter 31 Posttranscriptional Regulation of Gene Expression: mRNA turnover and microRNA
  • Chapter 5’s appendix on Protein Techniques has been removed and integrated into chapter 5
  • Canadian scientists, in particular Nobel Prize winners, have been highlighted and included throughout text

Supplements

All supplements have been updated in coordination with the Main title.
Please see Main title page for new to this edition information.

Instructor Supplements

OWLv2 6-months MindTap Reader Instant Access for Garrett, Biochemistry, First Canadian Edition  (ISBN-10: 0176674128 | ISBN-13: 9780176674120)

Conceived and developed by Chemistry instructors for Chemistry courses at the University of Massachusetts, Amherst, OWLv2 is the most widely used online chemistry solution in the world. OWLv2 not only saves instructors time and helps students learn, but also solves the very real teaching and learning prob-lems that instructors and students face in the classroom. OWLv2 meets students “ where they are” using a mastery learning approach and is based on principles of active learning, time on task, and prompt feedback. Students work through each concept- based problem until they master it. Students who need intensive help continue to work problems using a wealth of learning resources until they can show they have mastered the concepts. OWLv2 helps all students based on their individual needs. Adding to the challenge, each time a student tries a problem, OWLv2 randomizes the chemical, numerical and contextual aspects of the question. Rather than just memo-rizing a formula and plugging in new numbers, students must understand the under-lying chemical concepts before they gain mastery and move on.

OWLv2 24-months MindTap Reader Printed Access Card for Garrett, Biochemistry, First Canadian Edition  (ISBN-10: 0176674136 | ISBN-13: 9780176674137)
OWLv2 24-months MindTap Reader Instant Access for Garrett, Biochemistry, First Canadian Edition  (ISBN-10: 017667411X | ISBN-13: 9780176674113)
Student Solutions Manual for Biochemistry  (ISBN-10: 0176662421 | ISBN-13: 9780176662424)

Written by David K. Jemiolo ( Vassar College) and Steven M. Theg ( University of California, Davis) and revised and updated by the Canadian author team, this comprehensive combination resource contains all odd chapter summaries, important defi nitions, illustrations of major metabolic pathways, self- tests, and detailed solutions to all odd numbered end- of- chapter problems with answers.

Instructor's Resource CD for Biochemistry Nelson Education Teaching Advantage  (ISBN-10: 0176648321 | ISBN-13: 9780176648329)

The Nelson Education Teaching Advantage ( NETA) program delivers research- based instructor resources that promote student engagement and higher- order thinking to enable the success of Canadian students and educators. This Instructor's Resource CD Contains: NETA Test bank, NETA PowerPoint slides, DayOne Slides, Image Library, NETA Enriched Instructor Manual, and Instructor Solution Manual

Student Supplements

OWLv2 6-months MindTap Reader Instant Access for Garrett, Biochemistry, First Canadian Edition  (ISBN-10: 0176674128 | ISBN-13: 9780176674120)

Conceived and developed by Chemistry instructors for Chemistry courses at the University of Massachusetts, Amherst, OWLv2 is the most widely used online chemistry solution in the world. OWLv2 not only saves instructors time and helps students learn, but also solves the very real teaching and learning prob-lems that instructors and students face in the classroom. OWLv2 meets students “ where they are” using a mastery learning approach and is based on principles of active learning, time on task, and prompt feedback. Students work through each concept- based problem until they master it. Students who need intensive help continue to work problems using a wealth of learning resources until they can show they have mastered the concepts. OWLv2 helps all students based on their individual needs. Adding to the challenge, each time a student tries a problem, OWLv2 randomizes the chemical, numerical and contextual aspects of the question. Rather than just memo-rizing a formula and plugging in new numbers, students must understand the under-lying chemical concepts before they gain mastery and move on.

OWLv2 24-months MindTap Reader Printed Access Card for Garrett, Biochemistry, First Canadian Edition  (ISBN-10: 0176674136 | ISBN-13: 9780176674137)
OWLv2 24-months MindTap Reader Instant Access for Garrett, Biochemistry, First Canadian Edition  (ISBN-10: 017667411X | ISBN-13: 9780176674113)
Student Solutions Manual for Biochemistry  (ISBN-10: 0176662421 | ISBN-13: 9780176662424)

Written by David K. Jemiolo ( Vassar College) and Steven M. Theg ( University of California, Davis) and revised and updated by the Canadian author team, this comprehensive combination resource contains all odd chapter summaries, important defi nitions, illustrations of major metabolic pathways, self- tests, and detailed solutions to all odd numbered end- of- chapter problems with answers.