Nelson Higher Education

Higher Education

Biochemistry, 6th Edition

  • Reginald H. Garrett
  • Charles M. Grisham
  • ISBN-10: 1305577205
  • ISBN-13: 9781305577206
  • 1280 Pages | Hardcover
  • Previous Editions: 2013, 2009, 1999
  • COPYRIGHT: 2017 Published
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Overview

About the Product

Continuing Garrett and Grisham's innovative conceptual and organizing "Essential Questions" framework, BIOCHEMISTRY guides students through course concepts in a way that reveals the beauty and usefulness of biochemistry in the everyday world. Offering a balanced and streamlined presentation, this edition has been updated throughout with new material and revised presentations. For the first time, this book is integrated with OWLv2, a powerful online learning system for chemistry with book-specific end-of-chapter material that engages students and improves learning outcomes.

Features

  • Each chapter in this book is framed around an Essential Question that engages students in the material and encourages curiosity about the subject matter.

  • Human Biochemistry essays emphasize the central role of basic biochemistry in medicine and the health sciences with information on clinically important issues such as diet, diabetes, and cardiovascular health.

  • Critical Developments in Biochemistry essays emphasize recent and historical advances in the field, while A Deeper Look essays expand on the text, highlighting selected topics or experimental observations.

  • End-of-chapter summaries review and briefly answer the key questions posed in each section.

  • Reference lists at the end of each chapter make it easy for you to find additional information about each topic.

About the Author

Reginald H. Garrett

Reginald H. Garrett was educated in the Baltimore city public schools and at the Johns Hopkins University, where he received his Ph.D. in biology in 1968. Since that time, he has conducted research and taught biochemistry courses at the University of Virginia, where he is currently Professor of Biology. He is the author of numerous papers and review articles on biochemical, genetic, and molecular biological aspects of inorganic nitrogen metabolism. His early research focused on the pathway of nitrate assimilation in filamentous fungi. His investigations contributed substantially to our understanding of the enzymology, genetics, and regulation of this major pathway of biological nitrogen acquisition. More recently, he has collaborated in systems approaches to the metabolic basis of nutrition-related diseases. His research has been supported by grants from the National Institutes of Health, the National Science Foundation, and private industry. A member of the American Society for Biochemistry and Molecular Biology, Garrett is a former Fulbright Scholar, was twice Visiting Scholar at the University of Cambridge, and was Invited Professor at the University of Toulouse, France.

Charles M. Grisham

Charles M. Grisham received his B.S. in chemistry from the Illinois Institute of Technology in 1969 and his Ph.D. in chemistry from the University of Minnesota in 1973. Following a postdoctoral appointment at the Institute for Cancer Research in Philadelphia, he became Professor of Chemistry at the University of Virginia, where he teaches biochemistry, introductory chemistry, and physical chemistry. He has authored numerous papers and review articles on active transport of sodium, potassium, and calcium in mammalian systems, on protein kinase C, and on the applications of NMR and EPR spectroscopy to the study of biological systems. His work has been supported by the National Institutes of Health, the National Science Foundation, the Muscular Dystrophy Association of America, the Research Corporation, the American Heart Association and the American Chemical Society. A member of the American Society for Biochemistry and Molecular Biology, Grisham held the Knapp Chair in Chemistry in 1999 at the University of San Diego; was Visiting Scientist at the Aarhus University Institute of Physiology, Aarhus, Denmark, for two years; and received a Research Career Development Award from the National Institutes of Health.

Table of Contents

Part I: Molecular Components of Cells
1. The Facts of Life: Chemistry Is the Logic of Biological Phenomena
2. Water: The Medium of Life
3. Thermodynamics of Biological Systems
4. Amino Acids and the Peptide Bond
5. Proteins: Their Primary Structure and Biological Functions
6. Proteins: Secondary, Tertiary, and Quaternary Structure
7. Carbohydrates and the Glycoconjugates of Cell Surfaces
8. Lipids
9. Membranes and Membrane Transport
10. Nucleotides and Nucleic Acids
11. Structure of Nucleic Acids
12. Recombinant DNA, Cloning, Chimeric Genes, and Synthetic Biology
Part II: Protein Dynamics
13. Enzymes—Kinetics and Specificity
14. Mechanisms of Enzyme Action
15. Enzyme Regulation
16. Molecular Motors
Part III: Metabolism and Its Regulation
17. Metabolism: An Overview
18. Glycolysis
19. The Tricarboxylic Acid Cycle
20. Electron Transport and Oxidative Phosphorylation
21. Photosynthesis
22. Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway
23. Fatty Acid Catabolism
24. Lipid Biosynthesis
25. Nitrogen Acquisition and Amino Acid Metabolism
26. Synthesis and Degradation of Nucleotides
27. Metabolic Integration and Organ Specialization
Part IV: Information Transfer
28. DNA Metabolism: Replication, Recombination, and Repair
29. T ranscription and the Regulation of Gene Expression
30. Protein Synthesis
31. Completing the Protein Life Cycle: Folding, Processing, and Degradation
32. The Reception and Transmission of Extracellular Information
Abbreviated Answers to Problems
Index

New to this edition

  • Brand NEW “Deeper Look” Boxes have been added to Chapters 3, 4, 6, 7, 11, 12, 18, 23, and 30.
  • Brand NEW “Human Biochemistry” Boxes have been added to Chapters 7, 14, 16, 18, 19, 20, 24, and 26.
  • Brand NEW “Critical Developments in Biochemistry” Boxes in Chapters 4, 5, 6, 12, and 14.
  • Entirely new sections have been added to Chapters 5 and 12.
  • MANY New figures have been added and revised throughout.

Supplements

All supplements have been updated in coordination with the Main title.
Please see Main title page for new to this edition information.

Instructor Supplements

Instructor's Web Site  (ISBN-10: 1305882105 | ISBN-13: 9781305882102)

Everything you need for your course in one place! This collection of book-specific lecture and class tools is available online via www.cengage.com/login. Access and download PowerPoint presentations, images, sample chapters of the solutions manual, videos, and more.

Cengage Testing, powered by Cognero® Instant Access  (ISBN-10: 1305882377 | ISBN-13: 9781305882379)

Cengage Learning Testing Powered by Cognero is a flexible, online system that allows you to: author, edit, and manage test bank content from multiple Cengage Learning solutions create multiple test versions in an instant deliver tests from your LMS, your classroom or wherever you want.

Study Guide with Student Solutions Manual and Problems Book  (ISBN-10: 1305882407 | ISBN-13: 9781305882409)

This complete solutions manual and study guide is the perfect way to help your students prepare for exams, build problem-solving skills, and get the grade they want! This useful resource reinforces skills with activities and practice problems for each chapter. After completing the end-of-chapter exercises, they can check their answers for the all- questions.

OWLv2, 1 term (6 months) Instant Access  (ISBN-10: 1305636252 | ISBN-13: 9781305636255)

Students can use this ISBN at www.CENGAGEbrain.com to purchase instant access to OWLv2, the most trusted online learning solution for chemistry with the MindTap Reader version of Biochemistry 6e. Featuring chemist-developed content, OWLv2 is the only system designed to elevate thinking through Mastery Learning, allowing students to work at their own pace until they understand each concept and skill. Each time a student tries a problem, OWLv2 changes the chemicals, values, and sometimes even the wording of the question to ensure students are learning the concepts and not cheating the system. With detailed, instant feedback and interactive learning resources, students get the help they need when they need it. Now with improved student and instructor tools and greater functionality, OWLv2 is more robust than ever. Visit www.CENGAGE.com/owlv2 to learn more.

OWLv2, 4 terms (24 months) Instant Access  (ISBN-10: 1305636260 | ISBN-13: 9781305636262)

Students can use this ISBN at www.CENGAGEbrain.com to purchase instant access to OWLv2, the most trusted online learning solution for chemistry with the Biochemistry 6e. Featuring chemist-developed content, OWLv2 is the only system designed to elevate thinking through Mastery Learning, allowing students to work at their own pace until they understand each concept and skill. Each time a student tries a problem, OWLv2 changes the chemicals, values, and sometimes even the wording of the question to ensure students are learning the concepts and not cheating the system. With detailed, instant feedback and interactive learning resources, students get the help they need when they need it. Now with improved student and instructor tools and greater functionality, OWLv2 is more robust than ever. Visit www.CENGAGE.com/owlv2 to learn more.

Student Solutions eBook, 4 terms (24 months) Instant Access  (ISBN-10: 130588213X | ISBN-13: 9781305882133)

The eBook version of the Student Solutions Manual. Prepare for exams and succeed in your chemistry course with this comprehensive solutions manual! This manual contains answer and detailed solutions to all the in-chapter Exercises, Concept Checks, and Self-Assessment and Review Questions, as well as step-by-step solutions to selected odd-numbered end-of-chapter problems.

Student Supplements

Study Guide with Student Solutions Manual and Problems Book  (ISBN-10: 1305882407 | ISBN-13: 9781305882409)

This complete solutions manual and study guide is the perfect way to prepare for exams, build problem-solving skills, and get the grade you want! This useful resource reinforces skills with activities and practice problems for each chapter. After completing the end-of-chapter exercises, you can check your answers for the odd-numbered questions.

OWLv2, 1 term (6 months) Instant Access  (ISBN-10: 1305636252 | ISBN-13: 9781305636255)

If your instructor requires OWLv2 for this course, you can use this ISBN to purchase instant access with the MindTap Reader version of Biochemistry 6e at www.CENGAGEbrain.com. OWLv2 is the most trusted online learning solution for chemistry, proven to help you get a better grade. Featuring chemist-developed content, OWLv2 is the only system designed to elevate thinking through Mastery Learning, allowing you to work at your own pace until you understand each concept and skill. Each time you try a problem, OWLv2 changes the chemicals, values, and sometimes even the wording of the question to ensure you are learning the concepts and not just doing homework. With detailed, instant feedback and interactive learning resources, you get the help you need when you need it. Now with improved answer entry and input tools, OWLv2 is more robust than ever. Discover the power of OWLv2 and take your learning to a higher level. To learn more, visit www.CENGAGE.com/owlv2 or talk to your instructor.

OWLv2, 4 terms (24 months) Instant Access  (ISBN-10: 1305636260 | ISBN-13: 9781305636262)

If your instructor requires OWLv2 for this course, you can use this ISBN to purchase instant access with the MindTap Reader version of Biochemistry 6e at www.CENGAGEbrain.com. OWLv2 is the most trusted online learning solution for chemistry, proven to help you get a better grade. Featuring chemist-developed content, OWLv2 is the only system designed to elevate thinking through Mastery Learning, allowing you to work at your own pace until you understand each concept and skill. Each time you try a problem, OWLv2 changes the chemicals, values, and sometimes even the wording of the question to ensure you are learning the concepts and not just doing homework. With detailed, instant feedback and interactive learning resources, you get the help you need when you need it. Now with improved answer entry and input tools, OWLv2 is more robust than ever. Discover the power of OWLv2 and take your learning to a higher level. To learn more, visit www.CENGAGE.com/owlv2 or talk to your instructor.

Student Solutions eBook, 4 terms (24 months) Instant Access  (ISBN-10: 130588213X | ISBN-13: 9781305882133)

The eBook version of the Student Solutions Manual. Prepare for exams and succeed in your chemistry course with this comprehensive solutions manual! This manual contains answers and detailed solutions to all the in-chapter Exercises, Concept Checks, and Self-Assessment and Review Questions, as well as step-by-step solutions to selected odd-numbered end-of-chapter problems.

OWLv2 with Student Solutions Manual, 4 terms (24 months) Instant Access  (ISBN-10: 1305884752 | ISBN-13: 9781305884755)

If your instructor requires OWLv2 for this course, you can use this ISBN to purchase instant access with the MindTap Reader version of Biochemistry 6e and the Student Solutions Manual at www.CENGAGEbrain.com. OWLv2 is the most trusted online learning solution for chemistry, proven to help you get a better grade. Featuring chemist-developed content, OWLv2 is the only system designed to elevate thinking through Mastery Learning, allowing you to work at your own pace until you understand each concept and skill. Each time you try a problem, OWLv2 changes the chemicals, values, and sometimes even the wording of the question to ensure you are learning the concepts and not just doing homework. With detailed, instant feedback and interactive learning resources, you get the help you need when you need it. Now with improved answer entry and input tools, OWLv2 is more robust than ever. Discover the power of OWLv2 and take your learning to a higher level. To learn more, visit www.CENGAGE.com/owlv2 or talk to your instructor.