Nelson Higher Education

Higher Education

Case Studies in Cancer

  • Richard J. Lee
  • Jeremy S. Abramson
  • Richard A. Goldsby
  • ISBN-10: 0393679519
  • ISBN-13: 9780393679519
  • 0 Pages | Paperback
  • COPYRIGHT: 2019 Published
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About the Product

A case-based approach to cancer biology

Cancer is the focus of intense clinical and scientific interest. This research increasingly leverages our understanding of molecular biology for the development of targeted therapeutics. Well-selected case studies provide an opportunity to explain specific examples of cancers and their management in the context of engaging, patient-centered cases. This text is a clinical companion for Weinberg’s The Biology of Cancer. However, it includes sufficient background and explanatory detail to be used on its own.


  • FOCUSES ON THE MOLECULAR UNDERPINNINGS OF DISEASE The modern diagnosis and treatment of cancer is intricately tied to the molecular underpinnings of disease. Case Studies in Cancer highlights the broad range of malignancies in which known molecular pathways contribute to tumorigenesis as well as susceptibility or resistance to therapy.

  • CASES FOLLOW A BENCH TO BEDSIDE FRAMEWORK Every case highlights the relationship between the underlying molecular biology and the disease diagnosis and treatment. A logical, consistent organization of the cases ensures that the translation from “bench to bedside” is always apparent to the reader.

  • THE PERFECT COMPANION TO WEINBERG’S THE BIOLOGY OF CANCER As a clinical complement for The Biology of Cancer, this text gives exposure to the broad biological and clinical spectrum of cancer. It’s aimed at advanced undergraduates, basic science graduate students, and researchers who may not otherwise get exposure to the diagnosis and treatment of cancer in patient-centered contexts. First and second year medical students will benefit from the “bench to bedside” approach to better understand the biological rationale behind current treatments.

Table of Contents

Chapter 1: Overview of Cancer and Clinical Oncology
Chapter 2: Introduction to Cancer Therapy

Chapter 3: Cytotoxic Chemotherapy
Case 3-1: Testicular Cancer
Case 3-2: Pancreatic Cancer

Chapter 4: Protein Kinase Inhibition
Case 4-1: Chronic Myelogenous Leukemia
Case 4-2: Chronic Lymphocytic Leukemia
Case 4-3: Lung Cancer
Case 4-4: Metastatic Melanoma

Chapter 5: Inhibition of the PI3-Kinase/Akt/mTOR Pathway
Case 5-1: Renal Cell Carcinoma
Case 5-2: Follicular Lymphoma

Chapter 6: Hormone Therapy
Case 6-1: Breast Cancer
Case 6-2: Prostate Cancer

Chapter 7: Differentiation Therapy
Case 7-1: Acute Promyelocytic Leukemia

Chapter 8: Epigenetic Therapy
Case 8-1: Myelodysplastic Syndromes
Case 8-2: Cutaneous T-cell Lymphoma

Chapter 9: Targeting Protein Degradation and DNA Repair

Case 9-1: Hereditary Breast Cancer
Case 9-2: Multiple Myeloma

Chapter 10: Interference with the Tumor Microenvironment
Case 10-1: Colorectal Cancer
Case 10-2: Multiple Myeloma

Chapter 11: Immunological Strategies: Monoclonal Antibodies
Case 11-1: Non-Hodgkin Lymphoma
Case 11-2: Hodgkin Lymphoma
Case 11-3: Breast Cancer

Chapter 12: Immunological Strategies: Vaccination and Adoptive T-cell Transfer
Case 12-1: Cervical Cancer
Case 12-2: Acute Lymphoblastic Leukemia
Case 12-3: Metastatic Melanoma